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pentobarbital will reduce the level or effect of parecoxib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.pentobarbital will minimize the extent or influence of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with solid CYP3A4 inducers is no